The famous fresco "Crucifixion" by Cimabue in the left transept of the Upper Basilica of San Francesco in Assisi is a significant work of art. The painting depicts Christ on the Cross in isolation, symbolizing the pivotal moment of the Crucifixion that would change the course of history. Christ is portrayed prominently against the sky, with a crowd of people at his feet visibly shaken by the event. The composition and portrayal of emotion in this artwork showcase Cimabue's skill and artistic vision, despite the fading and altered colors over time.