Palazzo Papadopoli, erected in the second half of the 16th century by the Bergamo architect Giangiacomo dei Grigi, commissioned by the Coccina family from Bergamo, who had moved to Venice, reflects a distinctive architectural legacy. After belonging to the Coccina family, it passed into the hands of the Tiepolo family in 1748. In the 18th century, Giandomenico and Giambattista Tiepolo decorated the palace.
In the 19th century, various owners succeeded until 1864 when it became the residence of the counts Niccolò and Angelo Papadopoli. Girolamo Levi, in 1874-1875, carried out a neoclassical redesign, adding a wing and an extensive garden on the Grand Canal. The artistic direction was entrusted to the antiquarian Michelangelo Guggenheim, with collaboration from Cesare Rotta for the frescoes.
The palace, arranged in an L-shape with three floors, stands out for its symmetrical facade, decorated with Istrian stone in the style of Sebastiano Serlio. The facade facing the Grand Canal features a harmonious composition of Serlian motifs, with a full-arch portal on the ground floor and elegant windows and balconies on the noble floors.
The ensemble is enriched with details such as two relief coats of arms on the first noble floor, oval openings in the attic, and two obelisk-shaped pinnacles on the roof. The garden houses an authentic late Gothic well. The atrium of mirrors inside also stands out for its beauty.